DHFR

ENSG00000228716 - H. sapiens

Pathways

Go term Description
GO:0003729 mRNA binding
GO:0004146 dihydrofolate reductase activity
GO:0005542 folic acid binding
GO:0008144 drug binding
GO:0033560 folate reductase activity
GO:0051870 methotrexate binding
GO:0070402 NADPH binding
GO:0005515 protein binding
GO:0050661 NADP binding

Drugs

Drug name Description
METHOTREXATE Dihydrofolate reductase inhibitor
PEMETREXED Dihydrofolate reductase inhibitor
PRALATREXATE Dihydrofolate reductase inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
DFR1 S. cerevisiae

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000096717 SIRT1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.845945 View
ENSG00000105810 CDK6 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.845759 View
ENSG00000166501 PRKCB ENSG00000228716 DHFR H. sapiens SSL Slorth 0.845105 View
ENSG00000049759 NEDD4L ENSG00000228716 DHFR H. sapiens SSL Slorth 0.844295 View
ENSG00000137693 YAP1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.83905 View
ENSG00000058729 RIOK2 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.838564 View
ENSG00000116288 PARK7 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.837792 View
ENSG00000012048 BRCA1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.836887 View
ENSG00000075624 ACTB ENSG00000228716 DHFR H. sapiens SSL Slorth 0.836603 View
ENSG00000114166 KAT2B ENSG00000228716 DHFR H. sapiens SSL Slorth 0.835247 View
ENSG00000144554 FANCD2 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.830523 View
ENSG00000136807 CDK9 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.828385 View
ENSG00000109320 NFKB1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.82762 View
ENSG00000082898 XPO1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.824479 View
ENSG00000133316 WDR74 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.820138 View
ENSG00000154229 PRKCA ENSG00000228716 DHFR H. sapiens SSL Slorth 0.81876 View
ENSG00000169139 UBE2V2 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.816901 View
ENSG00000160803 UBQLN4 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.815439 View
ENSG00000149136 SSRP1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.814235 View
ENSG00000100644 HIF1A ENSG00000228716 DHFR H. sapiens SSL Slorth 0.813005 View
ENSG00000114767 RRP9 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.810557 View
ENSG00000121774 KHDRBS1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.807123 View
ENSG00000102882 MAPK3 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.805574 View
ENSG00000213341 CHUK ENSG00000228716 DHFR H. sapiens SSL Slorth 0.80554 View
ENSG00000101412 E2F1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.803655 View
ENSG00000151247 EIF4E ENSG00000228716 DHFR H. sapiens SSL Slorth 0.803206 View
ENSG00000130726 TRIM28 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.803041 View
ENSG00000169398 PTK2 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.802802 View
ENSG00000135446 CDK4 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.800406 View
ENSG00000109332 UBE2D3 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.797777 View
ENSG00000198668 CALM1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.79588 View
ENSG00000117676 RPS6KA1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.795052 View
ENSG00000164305 CASP3 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.794655 View
ENSG00000148400 NOTCH1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.793866 View
ENSG00000137486 ARRB1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.791631 View
ENSG00000121879 PIK3CA ENSG00000228716 DHFR H. sapiens SSL Slorth 0.787493 View
ENSG00000116030 SUMO1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.785373 View
ENSG00000096968 JAK2 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.78521 View
ENSG00000006451 RALA ENSG00000228716 DHFR H. sapiens SSL Slorth 0.780427 View
ENSG00000082701 GSK3B ENSG00000228716 DHFR H. sapiens SSL Slorth 0.779902 View