DHFR

ENSG00000228716 - H. sapiens

Pathways

Go term Description
GO:0003729 mRNA binding
GO:0004146 dihydrofolate reductase activity
GO:0005542 folic acid binding
GO:0008144 drug binding
GO:0033560 folate reductase activity
GO:0051870 methotrexate binding
GO:0070402 NADPH binding
GO:0005515 protein binding
GO:0050661 NADP binding

Drugs

Drug name Description
METHOTREXATE Dihydrofolate reductase inhibitor
PEMETREXED Dihydrofolate reductase inhibitor
PRALATREXATE Dihydrofolate reductase inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
DFR1 S. cerevisiae

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141867 BRD4 ENSG00000228716 DHFR H. sapiens SSL BioGRID 1.0 View
ENSG00000134371 CDC73 ENSG00000228716 DHFR H. sapiens SSL BioGRID 1.0 View
ENSG00000149554 CHEK1 ENSG00000228716 DHFR H. sapiens SSL BioGRID 1.0 View
ENSG00000228716 DHFR ENSG00000166483 WEE1 H. sapiens SSL BioGRID 1.0 View
ENSG00000109670 FBXW7 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.979562 View
ENSG00000133703 KRAS ENSG00000228716 DHFR H. sapiens SSL Slorth 0.976685 View
ENSG00000101146 RAE1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.964434 View
ENSG00000135486 HNRNPA1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.953446 View
ENSG00000097046 CDC7 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.945598 View
ENSG00000004700 RECQL ENSG00000228716 DHFR H. sapiens SSL Slorth 0.938601 View
ENSG00000167552 TUBA1A ENSG00000228716 DHFR H. sapiens SSL Slorth 0.935602 View
ENSG00000134086 VHL ENSG00000228716 DHFR H. sapiens SSL Slorth 0.92525 View
ENSG00000149554 CHEK1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.92179 View
ENSG00000138069 RAB1A ENSG00000228716 DHFR H. sapiens SSL Slorth 0.919131 View
ENSG00000108443 RPS6KB1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.913398 View
ENSG00000101868 POLA1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.910692 View
ENSG00000070010 UFD1L ENSG00000228716 DHFR H. sapiens SSL Slorth 0.905582 View
ENSG00000135624 CCT7 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.90086 View
ENSG00000128908 INO80 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.897988 View
ENSG00000123124 WWP1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.892722 View
ENSG00000062822 POLD1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.887203 View
ENSG00000110092 CCND1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.885374 View
ENSG00000138376 BARD1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.881073 View
ENSG00000154473 BUB3 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.880985 View
ENSG00000126261 UBA2 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.876646 View
ENSG00000168283 BMI1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.872389 View
ENSG00000177889 UBE2N ENSG00000228716 DHFR H. sapiens SSL Slorth 0.871194 View
ENSG00000110713 NUP98 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.870573 View
ENSG00000169750 RAC3 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.867911 View
ENSG00000127511 SIN3B ENSG00000228716 DHFR H. sapiens SSL Slorth 0.864416 View
ENSG00000117133 RPF1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.86337 View
ENSG00000111276 CDKN1B ENSG00000228716 DHFR H. sapiens SSL Slorth 0.861919 View
ENSG00000143799 PARP1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.86 View
ENSG00000078140 UBE2K ENSG00000228716 DHFR H. sapiens SSL Slorth 0.858815 View
ENSG00000131759 RARA ENSG00000228716 DHFR H. sapiens SSL Slorth 0.854933 View
ENSG00000162231 NXF1 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.854301 View
ENSG00000187608 ISG15 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.854284 View
ENSG00000175387 SMAD2 ENSG00000228716 DHFR H. sapiens SSL Slorth 0.852873 View
ENSG00000141564 RPTOR ENSG00000228716 DHFR H. sapiens SSL Slorth 0.849435 View
ENSG00000128245 YWHAH ENSG00000228716 DHFR H. sapiens SSL Slorth 0.847513 View