ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000044115 CTNNA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.786651 View
ENSG00000096746 HNRNPH3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.786407 View
ENSG00000103365 GGA2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.785295 View
ENSG00000141736 ERBB2 ENSG00000198517 MAFK H. sapiens SSL Slorth 0.785079 View
ENSG00000100804 PSMB5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.784672 View
ENSG00000068654 POLR1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.784553 View
ENSG00000042088 TDP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.78429 View
ENSG00000111642 CHD4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.784052 View
ENSG00000122218 COPA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.783702 View
ENSG00000055044 NOP58 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.783095 View
ENSG00000136273 HUS1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.782676 View
ENSG00000140807 NKD1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.782186 View
ENSG00000141736 ERBB2 ENSG00000157873 TNFRSF14 H. sapiens SSL Slorth 0.782067 View
ENSG00000133026 MYH10 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.781747 View
ENSG00000141736 ERBB2 ENSG00000182521 TBPL2 H. sapiens SSL Slorth 0.781598 View
ENSG00000141736 ERBB2 ENSG00000163918 RFC4 H. sapiens SSL Slorth 0.781408 View
ENSG00000047410 TPR ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.781016 View
ENSG00000141736 ERBB2 ENSG00000172340 SUCLG2 H. sapiens SSL Slorth 0.780899 View
ENSG00000065000 AP3D1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.780322 View
ENSG00000133119 RFC3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.77982 View
ENSG00000101945 SUV39H1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.779625 View
ENSG00000113460 BRIX1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.779611 View
ENSG00000141736 ERBB2 ENSG00000184445 KNTC1 H. sapiens SSL Slorth 0.779554 View
ENSG00000111581 NUP107 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.779504 View
ENSG00000077080 ACTL6B ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.778779 View
ENSG00000141736 ERBB2 ENSG00000146535 GNA12 H. sapiens SSL Slorth 0.778392 View
ENSG00000116141 MARK1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.778264 View
ENSG00000141736 ERBB2 ENSG00000169891 REPS2 H. sapiens SSL Slorth 0.777972 View
ENSG00000074201 CLNS1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.777909 View
ENSG00000117450 PRDX1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.777719 View
ENSG00000141736 ERBB2 ENSG00000176165 FOXG1 H. sapiens SSL Slorth 0.777568 View
ENSG00000109339 MAPK10 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.777551 View
ENSG00000141736 ERBB2 ENSG00000175745 NR2F1 H. sapiens SSL Slorth 0.777147 View
ENSG00000113643 RARS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.77696 View
ENSG00000141736 ERBB2 ENSG00000197943 PLCG2 H. sapiens SSL Slorth 0.77608 View
ENSG00000141736 ERBB2 ENSG00000166477 LEO1 H. sapiens SSL Slorth 0.77607 View
ENSG00000141736 ERBB2 ENSG00000177879 AP3S1 H. sapiens SSL Slorth 0.775965 View
ENSG00000080839 RBL1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.775617 View
ENSG00000141736 ERBB2 ENSG00000196576 PLXNB2 H. sapiens SSL Slorth 0.775426 View
ENSG00000104884 ERCC2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.775361 View