ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000001630 CYP51A1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.793763 View
ENSG00000092853 CLSPN ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.793753 View
ENSG00000141736 ERBB2 ENSG00000141985 SH3GL1 H. sapiens SSL Slorth 0.793711 View
ENSG00000141736 ERBB2 ENSG00000179094 PER1 H. sapiens SSL Slorth 0.793588 View
ENSG00000077254 USP33 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.793352 View
ENSG00000065150 IPO5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.793317 View
ENSG00000141736 ERBB2 ENSG00000162298 SYVN1 H. sapiens SSL Slorth 0.792561 View
ENSG00000104907 TRMT1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.79256 View
ENSG00000141736 ERBB2 ENSG00000168209 DDIT4 H. sapiens SSL Slorth 0.791944 View
ENSG00000138081 FBXO11 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.7916 View
ENSG00000099940 SNAP29 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.791514 View
ENSG00000108312 UBTF ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.791501 View
ENSG00000014138 POLA2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.791445 View
ENSG00000141736 ERBB2 ENSG00000155827 RNF20 H. sapiens SSL Slorth 0.791328 View
ENSG00000141736 ERBB2 ENSG00000166855 CLPX H. sapiens SSL Slorth 0.791072 View
ENSG00000141551 CSNK1D ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.79098 View
ENSG00000105221 AKT2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.790862 View
ENSG00000106089 STX1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.790686 View
ENSG00000124535 WRNIP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.790542 View
ENSG00000141736 ERBB2 ENSG00000185379 RAD51D H. sapiens SSL Slorth 0.790397 View
ENSG00000141736 ERBB2 ENSG00000160293 VAV2 H. sapiens SSL Slorth 0.790395 View
ENSG00000086598 TMED2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.790339 View
ENSG00000090376 IRAK3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.790122 View
ENSG00000075413 MARK3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.790077 View
ENSG00000134684 YARS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.789999 View
ENSG00000141736 ERBB2 ENSG00000197312 DDI2 H. sapiens SSL Slorth 0.788984 View
ENSG00000099995 SF3A1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.788982 View
ENSG00000136152 COG3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.788634 View
ENSG00000004975 DVL2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.788581 View
ENSG00000141736 ERBB2 ENSG00000148606 POLR3A H. sapiens SSL Slorth 0.788398 View
ENSG00000141736 ERBB2 ENSG00000147065 MSN H. sapiens SSL Slorth 0.788363 View
ENSG00000141736 ERBB2 ENSG00000154016 GRAP H. sapiens SSL Slorth 0.788336 View
ENSG00000131508 UBE2D2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.788277 View
ENSG00000141736 ERBB2 ENSG00000185236 RAB11B H. sapiens SSL Slorth 0.788146 View
ENSG00000065675 PRKCQ ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.787993 View
ENSG00000141736 ERBB2 ENSG00000180228 PRKRA H. sapiens SSL Slorth 0.787667 View
ENSG00000120738 EGR1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.787585 View
ENSG00000141736 ERBB2 ENSG00000154611 PSMA8 H. sapiens SSL Slorth 0.787276 View
ENSG00000141736 ERBB2 ENSG00000187840 EIF4EBP1 H. sapiens SSL Slorth 0.787263 View
ENSG00000141736 ERBB2 ENSG00000183020 AP2A2 H. sapiens SSL Slorth 0.787258 View