ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000161203 AP2M1 H. sapiens SSL Slorth 0.822562 View
ENSG00000141736 ERBB2 ENSG00000215114 UBXN2B H. sapiens SSL Slorth 0.822419 View
ENSG00000091009 RBM27 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.822303 View
ENSG00000141736 ERBB2 ENSG00000154928 EPHB1 H. sapiens SSL Slorth 0.822042 View
ENSG00000141736 ERBB2 ENSG00000176986 SEC24C H. sapiens SSL Slorth 0.821686 View
ENSG00000141736 ERBB2 ENSG00000197837 HIST4H4 H. sapiens SSL Slorth 0.821651 View
ENSG00000141736 ERBB2 ENSG00000184216 IRAK1 H. sapiens SSL Slorth 0.821531 View
ENSG00000141736 ERBB2 ENSG00000163914 RHO H. sapiens SSL Slorth 0.821085 View
ENSG00000100650 SRSF5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.820792 View
ENSG00000129562 DAD1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.820101 View
ENSG00000134070 IRAK2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.819856 View
ENSG00000108946 PRKAR1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.819786 View
ENSG00000130332 LSM7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.819777 View
ENSG00000004660 CAMKK1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.819397 View
ENSG00000115866 DARS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.818863 View
ENSG00000134352 IL6ST ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.818714 View
ENSG00000141736 ERBB2 ENSG00000168214 RBPJ H. sapiens SSL Slorth 0.818604 View
ENSG00000133627 ACTR3B ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.818285 View
ENSG00000102038 SMARCA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.818145 View
ENSG00000109819 PPARGC1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.817898 View
ENSG00000138107 ACTR1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.817881 View
ENSG00000141736 ERBB2 ENSG00000171109 MFN1 H. sapiens SSL Slorth 0.817689 View
ENSG00000141736 ERBB2 ENSG00000175832 ETV4 H. sapiens SSL Slorth 0.817539 View
ENSG00000141736 ERBB2 ENSG00000175592 FOSL1 H. sapiens SSL Slorth 0.817429 View
ENSG00000138346 DNA2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.817295 View
ENSG00000141736 ERBB2 ENSG00000198522 GPN1 H. sapiens SSL Slorth 0.817155 View
ENSG00000141736 ERBB2 ENSG00000185532 PRKG1 H. sapiens SSL Slorth 0.816707 View
ENSG00000136279 DBNL ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.816324 View
ENSG00000111361 EIF2B1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.816312 View
ENSG00000141736 ERBB2 ENSG00000164508 HIST1H2AA H. sapiens SSL Slorth 0.816075 View
ENSG00000141736 ERBB2 ENSG00000153107 ANAPC1 H. sapiens SSL Slorth 0.815547 View
ENSG00000141736 ERBB2 ENSG00000197114 ZGPAT H. sapiens SSL Slorth 0.815518 View
ENSG00000120656 TAF12 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.815466 View
ENSG00000141736 ERBB2 ENSG00000144744 UBA3 H. sapiens SSL Slorth 0.815217 View
ENSG00000141736 ERBB2 ENSG00000145495 MARCH6 H. sapiens SSL Slorth 0.815205 View
ENSG00000103549 RNF40 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.814724 View
ENSG00000064995 TAF11 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.814645 View
ENSG00000116604 MEF2D ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.814357 View
ENSG00000141736 ERBB2 ENSG00000147130 ZMYM3 H. sapiens SSL Slorth 0.81416 View
ENSG00000141736 ERBB2 ENSG00000150672 DLG2 H. sapiens SSL Slorth 0.813863 View