ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000213066 FGFR1OP H. sapiens SSL Slorth 0.856029 View
ENSG00000119487 MAPKAP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.855837 View
ENSG00000106976 DNM1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.855814 View
ENSG00000126524 SBDS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.855507 View
ENSG00000140262 TCF12 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.855492 View
ENSG00000141736 ERBB2 ENSG00000154310 TNIK H. sapiens SSL Slorth 0.854877 View
ENSG00000141736 ERBB2 ENSG00000184840 TMED9 H. sapiens SSL Slorth 0.854638 View
ENSG00000113312 TTC1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.854601 View
ENSG00000033327 GAB2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.854556 View
ENSG00000141736 ERBB2 ENSG00000170348 TMED10 H. sapiens SSL Slorth 0.854446 View
ENSG00000141736 ERBB2 ENSG00000175220 ARHGAP1 H. sapiens SSL Slorth 0.85441 View
ENSG00000138443 ABI2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.854117 View
ENSG00000105647 PIK3R2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.853693 View
ENSG00000141736 ERBB2 ENSG00000176105 YES1 H. sapiens SSL Slorth 0.853655 View
ENSG00000141736 ERBB2 ENSG00000181090 EHMT1 H. sapiens SSL Slorth 0.853178 View
ENSG00000141736 ERBB2 ENSG00000157227 MMP14 H. sapiens SSL Slorth 0.853038 View
ENSG00000123416 TUBA1B ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.852922 View
ENSG00000141736 ERBB2 ENSG00000142230 SAE1 H. sapiens SSL Slorth 0.852864 View
ENSG00000092847 AGO1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.852733 View
ENSG00000141736 ERBB2 ENSG00000149923 PPP4C H. sapiens SSL Slorth 0.852631 View
ENSG00000141736 ERBB2 ENSG00000184182 UBE2F H. sapiens SSL Slorth 0.852508 View
ENSG00000101336 HCK ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.852488 View
ENSG00000141736 ERBB2 ENSG00000204301 NOTCH4 H. sapiens SSL Slorth 0.852135 View
ENSG00000131475 VPS25 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.852059 View
ENSG00000141736 ERBB2 ENSG00000150457 LATS2 H. sapiens SSL Slorth 0.851981 View
ENSG00000141736 ERBB2 ENSG00000171763 SPATA5L1 H. sapiens SSL Slorth 0.851894 View
ENSG00000141736 ERBB2 ENSG00000182541 LIMK2 H. sapiens SSL Slorth 0.851812 View
ENSG00000101972 STAG2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.851597 View
ENSG00000141736 ERBB2 ENSG00000168488 ATXN2L H. sapiens SSL Slorth 0.851309 View
ENSG00000141736 ERBB2 ENSG00000158092 NCK1 H. sapiens SSL Slorth 0.850938 View
ENSG00000065054 SLC9A3R2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.850755 View
ENSG00000141736 ERBB2 ENSG00000172071 EIF2AK3 H. sapiens SSL Slorth 0.850213 View
ENSG00000108106 UBE2S ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.85015 View
ENSG00000102755 FLT1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.850114 View
ENSG00000141736 ERBB2 ENSG00000158560 DYNC1I1 H. sapiens SSL Slorth 0.850012 View
ENSG00000141736 ERBB2 ENSG00000166900 STX3 H. sapiens SSL Slorth 0.849747 View
ENSG00000141736 ERBB2 ENSG00000144566 RAB5A H. sapiens SSL Slorth 0.849619 View
ENSG00000112237 CCNC ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.849565 View
ENSG00000108883 EFTUD2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.849552 View
ENSG00000141736 ERBB2 ENSG00000244038 DDOST H. sapiens SSL Slorth 0.849368 View