ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000173801 JUP H. sapiens SSL Slorth 0.87052 View
ENSG00000141736 ERBB2 ENSG00000185513 L3MBTL1 H. sapiens SSL Slorth 0.870463 View
ENSG00000048052 HDAC9 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.870291 View
ENSG00000119707 RBM25 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.870287 View
ENSG00000141736 ERBB2 ENSG00000154473 BUB3 H. sapiens SSL Slorth 0.86958 View
ENSG00000141736 ERBB2 ENSG00000185787 MORF4L1 H. sapiens SSL Slorth 0.869465 View
ENSG00000141736 ERBB2 ENSG00000160867 FGFR4 H. sapiens SSL Slorth 0.869372 View
ENSG00000055130 CUL1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.869102 View
ENSG00000141736 ERBB2 ENSG00000151239 TWF1 H. sapiens SSL Slorth 0.868904 View
ENSG00000141736 ERBB2 ENSG00000166333 ILK H. sapiens SSL Slorth 0.868868 View
ENSG00000141736 ERBB2 ENSG00000183943 PRKX H. sapiens SSL Slorth 0.868779 View
ENSG00000094880 CDC23 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.868694 View
ENSG00000102981 PARD6A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.868676 View
ENSG00000141736 ERBB2 ENSG00000183431 SF3A3 H. sapiens SSL Slorth 0.868641 View
ENSG00000141736 ERBB2 ENSG00000159593 NAE1 H. sapiens SSL Slorth 0.868069 View
ENSG00000110955 ATP5B ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.86806 View
ENSG00000141736 ERBB2 ENSG00000165169 DYNLT3 H. sapiens SSL Slorth 0.867782 View
ENSG00000089289 IGBP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.867749 View
ENSG00000092820 EZR ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.867688 View
ENSG00000141736 ERBB2 ENSG00000156052 GNAQ H. sapiens SSL Slorth 0.867369 View
ENSG00000141736 ERBB2 ENSG00000186153 WWOX H. sapiens SSL Slorth 0.867339 View
ENSG00000141736 ERBB2 ENSG00000166595 FAM96B H. sapiens SSL Slorth 0.867179 View
ENSG00000141736 ERBB2 ENSG00000158711 ELK4 H. sapiens SSL Slorth 0.867021 View
ENSG00000141736 ERBB2 ENSG00000163629 PTPN13 H. sapiens SSL Slorth 0.866981 View
ENSG00000141736 ERBB2 ENSG00000151461 UPF2 H. sapiens SSL Slorth 0.866839 View
ENSG00000141736 ERBB2 ENSG00000170606 HSPA4 H. sapiens SSL Slorth 0.866817 View
ENSG00000088832 FKBP1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.86657 View
ENSG00000141736 ERBB2 ENSG00000151748 SAV1 H. sapiens SSL Slorth 0.86642 View
ENSG00000138758 SEPT11 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.866288 View
ENSG00000103496 STX4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.866203 View
ENSG00000095951 HIVEP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.866061 View
ENSG00000141736 ERBB2 ENSG00000183495 EP400 H. sapiens SSL Slorth 0.865879 View
ENSG00000123358 NR4A1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.865677 View
ENSG00000103653 CSK ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.865474 View
ENSG00000101442 ACTR5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.865049 View
ENSG00000141736 ERBB2 ENSG00000166167 BTRC H. sapiens SSL Slorth 0.864944 View
ENSG00000141736 ERBB2 ENSG00000276618 RAD17 H. sapiens SSL Slorth 0.864918 View
ENSG00000141736 ERBB2 ENSG00000142655 PEX14 H. sapiens SSL Slorth 0.864753 View
ENSG00000131558 EXOC4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.864609 View
ENSG00000141736 ERBB2 ENSG00000178896 EXOSC4 H. sapiens SSL Slorth 0.864587 View