ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000132906 CASP9 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.886541 View
ENSG00000141736 ERBB2 ENSG00000176890 TYMS H. sapiens SSL Slorth 0.886476 View
ENSG00000141736 ERBB2 ENSG00000182621 PLCB1 H. sapiens SSL Slorth 0.886329 View
ENSG00000141736 ERBB2 ENSG00000180098 TRNAU1AP H. sapiens SSL Slorth 0.886311 View
ENSG00000141736 ERBB2 ENSG00000179218 CALR H. sapiens SSL Slorth 0.886153 View
ENSG00000141736 ERBB2 ENSG00000158987 RAPGEF6 H. sapiens SSL Slorth 0.885904 View
ENSG00000007168 PAFAH1B1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.885887 View
ENSG00000141736 ERBB2 ENSG00000156802 ATAD2 H. sapiens SSL Slorth 0.885601 View
ENSG00000141736 ERBB2 ENSG00000178573 MAF H. sapiens SSL Slorth 0.885532 View
ENSG00000141736 ERBB2 ENSG00000143256 PFDN2 H. sapiens SSL Slorth 0.885327 View
ENSG00000105325 FZR1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.885119 View
ENSG00000141736 ERBB2 ENSG00000169756 LIMS1 H. sapiens SSL Slorth 0.885043 View
ENSG00000127955 GNAI1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.885038 View
ENSG00000141736 ERBB2 ENSG00000174405 LIG4 H. sapiens SSL Slorth 0.884802 View
ENSG00000065548 ZC3H15 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.884701 View
ENSG00000141736 ERBB2 ENSG00000254505 CHMP4A H. sapiens SSL Slorth 0.884699 View
ENSG00000141736 ERBB2 ENSG00000171497 PPID H. sapiens SSL Slorth 0.884587 View
ENSG00000105402 NAPA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.884441 View
ENSG00000121653 MAPK8IP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.884407 View
ENSG00000080824 HSP90AA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.884378 View
ENSG00000141736 ERBB2 ENSG00000184481 FOXO4 H. sapiens SSL Slorth 0.884361 View
ENSG00000035928 RFC1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.884294 View
ENSG00000141736 ERBB2 ENSG00000151422 FER H. sapiens SSL Slorth 0.884031 View
ENSG00000116288 PARK7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.88386 View
ENSG00000141736 ERBB2 ENSG00000162733 DDR2 H. sapiens SSL Slorth 0.883794 View
ENSG00000141736 ERBB2 ENSG00000198925 ATG9A H. sapiens SSL Slorth 0.883761 View
ENSG00000054116 TRAPPC3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.88374 View
ENSG00000141736 ERBB2 ENSG00000149930 TAOK2 H. sapiens SSL Slorth 0.883726 View
ENSG00000141736 ERBB2 ENSG00000170296 GABARAP H. sapiens SSL Slorth 0.883707 View
ENSG00000141736 ERBB2 ENSG00000196296 ATP2A1 H. sapiens SSL Slorth 0.88368 View
ENSG00000019995 ZRANB1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.883517 View
ENSG00000141736 ERBB2 ENSG00000151694 ADAM17 H. sapiens SSL Slorth 0.883491 View
ENSG00000130713 EXOSC2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.883156 View
ENSG00000133895 MEN1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.882893 View
ENSG00000141736 ERBB2 ENSG00000198648 STK39 H. sapiens SSL Slorth 0.882718 View
ENSG00000141736 ERBB2 ENSG00000149269 PAK1 H. sapiens SSL Slorth 0.882496 View
ENSG00000100347 SAMM50 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.882224 View
ENSG00000049618 ARID1B ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.881684 View
ENSG00000141736 ERBB2 ENSG00000174791 RIN1 H. sapiens SSL Slorth 0.881636 View
ENSG00000141736 ERBB2 ENSG00000163902 RPN1 H. sapiens SSL Slorth 0.881623 View