ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000142507 PSMB6 H. sapiens SSL Slorth 0.775286 View
ENSG00000083168 KAT6A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.775105 View
ENSG00000089737 DDX24 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.774482 View
ENSG00000141736 ERBB2 ENSG00000157456 CCNB2 H. sapiens SSL Slorth 0.774279 View
ENSG00000141736 ERBB2 ENSG00000205220 PSMB10 H. sapiens SSL Slorth 0.773816 View
ENSG00000141736 ERBB2 ENSG00000269858 EGLN2 H. sapiens SSL Slorth 0.773366 View
ENSG00000141736 ERBB2 ENSG00000149182 ARFGAP2 H. sapiens SSL Slorth 0.773147 View
ENSG00000113282 CLINT1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.772948 View
ENSG00000141736 ERBB2 ENSG00000167670 CHAF1A H. sapiens SSL Slorth 0.772905 View
ENSG00000137055 PLAA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.772697 View
ENSG00000013275 PSMC4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.772659 View
ENSG00000134014 ELP3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.772611 View
ENSG00000141736 ERBB2 ENSG00000241553 ARPC4 H. sapiens SSL Slorth 0.772436 View
ENSG00000115946 PNO1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.772414 View
ENSG00000130479 MAP1S ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.771755 View
ENSG00000141736 ERBB2 ENSG00000172602 RND1 H. sapiens SSL Slorth 0.771704 View
ENSG00000141736 ERBB2 ENSG00000167258 CDK12 H. sapiens SSL Slorth 0.771686 View
ENSG00000141736 ERBB2 ENSG00000215041 NEURL4 H. sapiens SSL Slorth 0.771429 View
ENSG00000141736 ERBB2 ENSG00000196781 TLE1 H. sapiens SSL Slorth 0.77135 View
ENSG00000113810 SMC4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.771278 View
ENSG00000065135 GNAI3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.771061 View
ENSG00000136504 KAT7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.770938 View
ENSG00000104517 UBR5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.770738 View
ENSG00000113615 SEC24A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.770603 View
ENSG00000141736 ERBB2 ENSG00000168918 INPP5D H. sapiens SSL Slorth 0.770351 View
ENSG00000141736 ERBB2 ENSG00000198176 TFDP1 H. sapiens SSL Slorth 0.770311 View
ENSG00000141736 ERBB2 ENSG00000173545 ZNF622 H. sapiens SSL Slorth 0.769929 View
ENSG00000141736 ERBB2 ENSG00000197930 ERO1A H. sapiens SSL Slorth 0.769616 View
ENSG00000041357 PSMA4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.769475 View
ENSG00000089685 BIRC5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.769419 View
ENSG00000141736 ERBB2 ENSG00000180008 SOCS4 H. sapiens SSL Slorth 0.769388 View
ENSG00000141736 ERBB2 ENSG00000163029 SMC6 H. sapiens SSL Slorth 0.769226 View
ENSG00000141736 ERBB2 ENSG00000167548 KMT2D H. sapiens SSL Slorth 0.769077 View
ENSG00000104856 RELB ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.768941 View
ENSG00000133226 SRRM1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.768913 View
ENSG00000141736 ERBB2 ENSG00000204231 RXRB H. sapiens SSL Slorth 0.768834 View
ENSG00000109929 SC5D ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.768538 View
ENSG00000141736 ERBB2 ENSG00000161270 NPHS1 H. sapiens SSL Slorth 0.768316 View
ENSG00000141736 ERBB2 ENSG00000175093 SPSB4 H. sapiens SSL Slorth 0.768091 View
ENSG00000009335 UBE3C ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.768087 View