BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000070831 CDC42 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.921629 View
ENSG00000157764 BRAF ENSG00000198625 MDM4 H. sapiens SSL Slorth 0.921413 View
ENSG00000157764 BRAF ENSG00000220205 VAMP2 H. sapiens SSL Slorth 0.921331 View
ENSG00000116350 SRSF4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.921314 View
ENSG00000134058 CDK7 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.921135 View
ENSG00000157764 BRAF ENSG00000171132 PRKCE H. sapiens SDL Slorth 0.921124 View
ENSG00000148908 RGS10 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.921099 View
ENSG00000150457 LATS2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.920767 View
ENSG00000157764 BRAF ENSG00000184634 MED12 H. sapiens SSL Slorth 0.920431 View
ENSG00000114423 CBLB ENSG00000157764 BRAF H. sapiens SDL Slorth 0.92037 View
ENSG00000010017 RANBP9 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.920197 View
ENSG00000136930 PSMB7 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.919943 View
ENSG00000157764 BRAF ENSG00000170315 UBB H. sapiens SSL Slorth 0.919897 View
ENSG00000157764 BRAF ENSG00000185236 RAB11B H. sapiens SSL Slorth 0.919765 View
ENSG00000123200 ZC3H13 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.919583 View
ENSG00000157764 BRAF ENSG00000170345 FOS H. sapiens SDL Slorth 0.919572 View
ENSG00000143632 ACTA1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.9195 View
ENSG00000157764 BRAF ENSG00000160803 UBQLN4 H. sapiens SDL Slorth 0.919367 View
ENSG00000106462 EZH2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.91908 View
ENSG00000157764 BRAF ENSG00000187735 TCEA1 H. sapiens SSL Slorth 0.918973 View
ENSG00000157764 BRAF ENSG00000170734 POLH H. sapiens SSL Slorth 0.91897 View
ENSG00000116473 RAP1A ENSG00000157764 BRAF H. sapiens SDL Slorth 0.918849 View
ENSG00000157764 BRAF ENSG00000198522 GPN1 H. sapiens SSL Slorth 0.918661 View
ENSG00000137309 HMGA1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.918446 View
ENSG00000099956 SMARCB1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.918252 View
ENSG00000157764 BRAF ENSG00000221983 UBA52 H. sapiens SDL Slorth 0.918237 View
ENSG00000115085 ZAP70 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.918235 View
ENSG00000157764 BRAF ENSG00000166233 ARIH1 H. sapiens SSL Slorth 0.917962 View
ENSG00000103769 RAB11A ENSG00000157764 BRAF H. sapiens SDL Slorth 0.917937 View
ENSG00000147065 MSN ENSG00000157764 BRAF H. sapiens SSL Slorth 0.917832 View
ENSG00000109458 GAB1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.917807 View
ENSG00000070756 PABPC1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.917752 View
ENSG00000157764 BRAF ENSG00000164934 DCAF13 H. sapiens SSL Slorth 0.917648 View
ENSG00000157764 BRAF ENSG00000204843 DCTN1 H. sapiens SSL Slorth 0.917435 View
ENSG00000107643 MAPK8 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.917397 View
ENSG00000157764 BRAF ENSG00000176105 YES1 H. sapiens SSL Slorth 0.917316 View
ENSG00000103197 TSC2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.917167 View
ENSG00000157764 BRAF ENSG00000196235 SUPT5H H. sapiens SSL Slorth 0.917139 View
ENSG00000157764 BRAF ENSG00000197122 SRC H. sapiens SSL Slorth 0.91706 View
ENSG00000121653 MAPK8IP1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.917018 View