EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000186908 ZDHHC17 H. sapiens SDL Slorth 0.906989 View
ENSG00000146648 EGFR ENSG00000155959 VBP1 H. sapiens SSL Slorth 0.90696 View
ENSG00000146648 EGFR ENSG00000198522 GPN1 H. sapiens SSL Slorth 0.906883 View
ENSG00000146648 EGFR ENSG00000185236 RAB11B H. sapiens SSL Slorth 0.90675 View
ENSG00000110107 PRPF19 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.906732 View
ENSG00000146648 EGFR ENSG00000174371 EXO1 H. sapiens SSL Slorth 0.90671 View
ENSG00000116898 MRPS15 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.906658 View
ENSG00000142731 PLK4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.906626 View
ENSG00000146648 EGFR ENSG00000166167 BTRC H. sapiens SDL Slorth 0.906582 View
ENSG00000087586 AURKA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.906549 View
ENSG00000146648 EGFR ENSG00000156976 EIF4A2 H. sapiens SDL Slorth 0.906547 View
ENSG00000104825 NFKBIB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.906543 View
ENSG00000146648 EGFR ENSG00000197299 BLM H. sapiens SSL Slorth 0.906513 View
ENSG00000146648 EGFR ENSG00000177733 HNRNPA0 H. sapiens SSL Slorth 0.90632 View
ENSG00000144029 MRPS5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.906237 View
ENSG00000105173 CCNE1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.906106 View
ENSG00000146648 EGFR ENSG00000169016 E2F6 H. sapiens SDL Slorth 0.906096 View
ENSG00000146648 EGFR ENSG00000166598 HSP90B1 H. sapiens SSL Slorth 0.905676 View
ENSG00000146648 EGFR ENSG00000175216 CKAP5 H. sapiens SSL Slorth 0.905655 View
ENSG00000146648 EGFR ENSG00000169375 SIN3A H. sapiens SDL Slorth 0.905352 View
ENSG00000146648 EGFR ENSG00000160145 KALRN H. sapiens SDL Slorth 0.905291 View
ENSG00000146648 EGFR ENSG00000177283 FZD8 H. sapiens SDL Slorth 0.905268 View
ENSG00000146648 EGFR ENSG00000220205 VAMP2 H. sapiens SSL Slorth 0.905158 View
ENSG00000146648 EGFR ENSG00000172939 OXSR1 H. sapiens SDL Slorth 0.905137 View
ENSG00000136936 XPA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.905109 View
ENSG00000146648 EGFR ENSG00000185920 PTCH1 H. sapiens SDL Slorth 0.90473 View
ENSG00000079999 KEAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.904668 View
ENSG00000146648 EGFR ENSG00000168066 SF1 H. sapiens SSL Slorth 0.904641 View
ENSG00000146648 EGFR ENSG00000178562 CD28 H. sapiens SSL Slorth 0.904572 View
ENSG00000058729 RIOK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.904436 View
ENSG00000106004 HOXA5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.904426 View
ENSG00000146648 EGFR ENSG00000154174 TOMM70 H. sapiens SSL Slorth 0.904422 View
ENSG00000146648 EGFR ENSG00000170296 GABARAP H. sapiens SSL Slorth 0.904411 View
ENSG00000146648 EGFR ENSG00000186716 BCR H. sapiens SSL Slorth 0.904258 View
ENSG00000116604 MEF2D ENSG00000146648 EGFR H. sapiens SDL Slorth 0.904185 View
ENSG00000078140 UBE2K ENSG00000146648 EGFR H. sapiens SDL Slorth 0.904038 View
ENSG00000146648 EGFR ENSG00000197323 TRIM33 H. sapiens SSL Slorth 0.903842 View
ENSG00000138794 CASP6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.903697 View
ENSG00000093009 CDC45 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.903694 View
ENSG00000146648 EGFR ENSG00000166888 STAT6 H. sapiens SSL Slorth 0.903663 View