EGFR - PTCH1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
EGFR	ENSG00000146648	glioma NSCLC	AFATINIB CETUXIMAB ERLOTINIB GEFITINIB LAPATINIB PANITUMUMAB VANDETANIB	glycoprotein binding chromatin binding double-stranded DNA binding MAP kinase kinase kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity transmembrane signaling receptor activity epidermal growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity integrin binding protein binding calmodulin binding ATP binding enzyme binding protein kinase binding protein phosphatase binding ubiquitin protein ligase binding identical protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity epidermal growth factor binding actin filament binding cadherin binding involved in cell-cell adhesion nitric-oxide synthase regulator activity protein domain specific binding	let-23 (C. elegans) Egfr (D. melanogaster)
PTCH1	ENSG00000185920	skin basal cell medulloblastoma	No drugs in record	patched binding smoothened binding protein binding hedgehog receptor activity heparin binding cholesterol binding cyclin binding protein complex binding hedgehog family protein binding	NCR1 (S. cerevisiae) ptc-1 (C. elegans) ptc-3 (C. elegans) ptc-2 (C. elegans) ptc (D. melanogaster)