PDGFRB

ENSG00000113721 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004992 platelet activating factor receptor activity
GO:0005017 platelet-derived growth factor-activated receptor activity
GO:0005019 platelet-derived growth factor beta-receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0038085 vascular endothelial growth factor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048407 platelet-derived growth factor binding

Drugs

Drug name Description
BECAPLERMIN Platelet-derived growth factor receptor agonist
DASATINIB Tyrosine-protein kinase ABL inhibitor
IMATINIB Tyrosine-protein kinase ABL inhibitor
NINTEDANIB Platelet-derived growth factor receptor inhibitor
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
MPN
AML
CMML
CML

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000113721 PDGFRB ENSG00000158290 CUL4B H. sapiens SSL Slorth 0.949421 View
ENSG00000113721 PDGFRB ENSG00000176105 YES1 H. sapiens SDL Slorth 0.949337 View
ENSG00000113721 PDGFRB ENSG00000135018 UBQLN1 H. sapiens SDL Slorth 0.949324 View
ENSG00000113721 PDGFRB ENSG00000137171 KLC4 H. sapiens SDL Slorth 0.949255 View
ENSG00000113721 PDGFRB ENSG00000154229 PRKCA H. sapiens SSL Slorth 0.949224 View
ENSG00000113721 PDGFRB ENSG00000165527 ARF6 H. sapiens SDL Slorth 0.94921 View
ENSG00000113721 PDGFRB ENSG00000122779 TRIM24 H. sapiens SSL Slorth 0.949166 View
ENSG00000113721 PDGFRB ENSG00000147274 RBMX H. sapiens SDL Slorth 0.949165 View
ENSG00000113721 PDGFRB ENSG00000198873 GRK5 H. sapiens SDL Slorth 0.949019 View
ENSG00000061938 TNK2 ENSG00000113721 PDGFRB H. sapiens SSL Slorth 0.948928 View
ENSG00000113721 PDGFRB ENSG00000128708 HAT1 H. sapiens SSL Slorth 0.948925 View
ENSG00000113721 PDGFRB ENSG00000144028 SNRNP200 H. sapiens SSL Slorth 0.948918 View
ENSG00000087586 AURKA ENSG00000113721 PDGFRB H. sapiens SSL Slorth 0.948842 View
ENSG00000113721 PDGFRB ENSG00000143256 PFDN2 H. sapiens SDL Slorth 0.948805 View
ENSG00000113721 PDGFRB ENSG00000130119 GNL3L H. sapiens SSL Slorth 0.948759 View
ENSG00000113721 PDGFRB ENSG00000165025 SYK H. sapiens SDL Slorth 0.948673 View
ENSG00000060069 CTDP1 ENSG00000113721 PDGFRB H. sapiens SSL Slorth 0.948527 View
ENSG00000113721 PDGFRB ENSG00000141027 NCOR1 H. sapiens SSL Slorth 0.948485 View
ENSG00000113721 PDGFRB ENSG00000156970 BUB1B H. sapiens SSL Slorth 0.948473 View
ENSG00000113721 PDGFRB ENSG00000196591 HDAC2 H. sapiens SSL Slorth 0.948404 View
ENSG00000113721 PDGFRB ENSG00000183684 ALYREF H. sapiens SDL Slorth 0.948392 View
ENSG00000107872 FBXL15 ENSG00000113721 PDGFRB H. sapiens SDL Slorth 0.94834 View
ENSG00000113721 PDGFRB ENSG00000130402 ACTN4 H. sapiens SDL Slorth 0.948329 View
ENSG00000100029 PES1 ENSG00000113721 PDGFRB H. sapiens SDL Slorth 0.948244 View
ENSG00000113721 PDGFRB ENSG00000158092 NCK1 H. sapiens SDL Slorth 0.9482 View
ENSG00000113721 PDGFRB ENSG00000119403 PHF19 H. sapiens SDL Slorth 0.94819 View
ENSG00000113721 PDGFRB ENSG00000122692 SMU1 H. sapiens SDL Slorth 0.948148 View
ENSG00000113721 PDGFRB ENSG00000160293 VAV2 H. sapiens SDL Slorth 0.948063 View
ENSG00000113721 PDGFRB ENSG00000134057 CCNB1 H. sapiens SDL Slorth 0.947994 View
ENSG00000113721 PDGFRB ENSG00000147614 ATP6V0D2 H. sapiens SDL Slorth 0.947978 View
ENSG00000113721 PDGFRB ENSG00000162909 CAPN2 H. sapiens SSL Slorth 0.947941 View
ENSG00000105612 DNASE2 ENSG00000113721 PDGFRB H. sapiens SDL Slorth 0.947887 View
ENSG00000113721 PDGFRB ENSG00000130479 MAP1S H. sapiens SSL Slorth 0.94781 View
ENSG00000113721 PDGFRB ENSG00000172534 HCFC1 H. sapiens SDL Slorth 0.947767 View
ENSG00000109320 NFKB1 ENSG00000113721 PDGFRB H. sapiens SSL Slorth 0.947682 View
ENSG00000085832 EPS15 ENSG00000113721 PDGFRB H. sapiens SSL Slorth 0.947628 View
ENSG00000113721 PDGFRB ENSG00000143093 STRIP1 H. sapiens SDL Slorth 0.947581 View
ENSG00000113721 PDGFRB ENSG00000198836 OPA1 H. sapiens SSL Slorth 0.947474 View
ENSG00000113721 PDGFRB ENSG00000153201 RANBP2 H. sapiens SSL Slorth 0.94747 View
ENSG00000112118 MCM3 ENSG00000113721 PDGFRB H. sapiens SSL Slorth 0.947447 View