SIR2 - TOP2

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SIR2	YDL042C	No diseases in record	No drugs in record	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides NAD-dependent histone deacetylase activity NAD-dependent histone deacetylase activity (H3-K14 specific) hydrolase activity nucleosome binding zinc ion binding NAD binding NAD+ binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) histone deacetylase activity (H3-K4 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity histone deacetylase activity (H4-K16 specific) histone deacetylase activity (H3-K14 specific)	SIRT1 (H. sapiens)
TOP2	YNL088W	No diseases in record	No drugs in record	DNA topoisomerase type II (ATP-hydrolyzing) activity ATP binding DNA binding nucleotide binding DNA topoisomerase activity isomerase activity metal ion binding four-way junction DNA binding mRNA binding protein binding chromatin binding rDNA binding satellite DNA binding DNA topoisomerase II activity	TOP2A (H. sapiens) TOP2B (H. sapiens)