PIK3CA - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PIK3CA	ENSG00000121879	colorectal gastric glioblastoma breast	No drugs in record	protein serine/threonine kinase activity protein binding ATP binding kinase activity 1-phosphatidylinositol-3-kinase activity protein kinase activator activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity	VPS34 (S. cerevisiae)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)