KMT2A - WRN

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
KMT2A	ENSG00000118058	AML ALL	No drugs in record	core promoter sequence-specific DNA binding AT DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding histone-lysine N-methyltransferase activity histone methyltransferase activity (H3-K4 specific) identical protein binding protein homodimerization activity transcription regulatory region DNA binding unmethylated CpG binding lysine-acetylated histone binding	SET1 (S. cerevisiae) trx (D. melanogaster)
WRN	ENSG00000165392	osteosarcoma meningioma other tumour types	No drugs in record	magnesium ion binding Y-form DNA binding bubble DNA binding DNA binding DNA helicase activity chromatin binding ATP-dependent DNA helicase activity helicase activity exonuclease activity protein binding ATP binding 3'-5' exonuclease activity four-way junction helicase activity ATPase activity manganese ion binding protein complex binding protein homodimerization activity 3'-5' DNA helicase activity ATP-dependent 3'-5' DNA helicase activity G-quadruplex DNA binding	SGS1 (S. cerevisiae) wrn-1 (C. elegans)