MRE11 - KIT

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MRE11	ENSG00000020922	No diseases in record	No drugs in record	hydrolase activity exonuclease activity endonuclease activity protein complex scaffold activity manganese ion binding nuclease activity 3'-5' exonuclease activity G-quadruplex DNA binding single-stranded telomeric DNA binding double-stranded telomeric DNA binding telomeric DNA binding endodeoxyribonuclease activity adenylate kinase activity protein binding DNA end binding single-stranded DNA endodeoxyribonuclease activity Y-form DNA binding single-stranded DNA 3'-5' exodeoxyribonuclease activity double-stranded DNA 3'-5' exodeoxyribonuclease activity	MRE11 (S. cerevisiae) mre-11 (C. elegans)
KIT	ENSG00000157404	GIST AML TGCT mastocytosis mucosal melanoma epithelioma	CABOZANTINIB DASATINIB IMATINIB LENVATINIB PAZOPANIB PONATINIB REGORAFENIB SORAFENIB SUNITINIB	protease binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity stem cell factor receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding cytokine binding protein homodimerization activity metal ion binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Pvr (D. melanogaster)