SIR2 - ISW2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SIR2	YDL042C	No diseases in record	No drugs in record	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides NAD-dependent histone deacetylase activity NAD-dependent histone deacetylase activity (H3-K14 specific) hydrolase activity nucleosome binding zinc ion binding NAD binding NAD+ binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) histone deacetylase activity (H3-K4 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity histone deacetylase activity (H4-K16 specific) histone deacetylase activity (H3-K14 specific)	SIRT1 (H. sapiens)
ISW2	YOR304W	No diseases in record	No drugs in record	ATP binding DNA translocase activity helicase activity DNA binding hydrolase activity nucleotide binding chromatin binding centromeric DNA binding nucleic acid binding single-stranded DNA binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides nucleosome binding	SMARCA1 (H. sapiens) SMARCA5 (H. sapiens)