SAE1 - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SAE1	ENSG00000142230	No diseases in record	No drugs in record	ubiquitin activating enzyme activity protein binding protein C-terminus binding enzyme activator activity ATP-dependent protein binding protein heterodimerization activity SUMO activating enzyme activity	AOS1 (S. cerevisiae) Aos1 (D. melanogaster)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)