USP8 - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
USP8	ENSG00000138592	corticotroph adenoma	No drugs in record	cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding SH3 domain binding cadherin binding involved in cell-cell adhesion	DOA4 (S. cerevisiae) UBP5 (S. cerevisiae)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)