FH - SMAD4

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
FH	ENSG00000091483	leiomyomatosis renal	No drugs in record	fumarate hydratase activity protein binding iron chaperone activity ferrous iron binding ferroxidase activity 2 iron, 2 sulfur cluster binding ferric iron binding	FUM1 (S. cerevisiae) fum-1 (C. elegans)
SMAD4	ENSG00000141646	colorectal pancreatic small intestine gastrointestinal polyp	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding chromatin binding protein binding collagen binding transforming growth factor beta receptor, common-partner cytoplasmic mediator activity identical protein binding protein homodimerization activity transcription regulatory region DNA binding metal ion binding protein heterodimerization activity I-SMAD binding R-SMAD binding transcription factor activity, protein binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding	Med (D. melanogaster)