ADAM10 - SMAD2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
ADAM10	ENSG00000137845	No diseases in record	No drugs in record	endopeptidase activity metalloendopeptidase activity receptor binding integrin binding protein binding metallopeptidase activity SH3 domain binding protein kinase binding protein homodimerization activity metal ion binding	sup-17 (C. elegans)
SMAD2	ENSG00000175387	colorectal carcinoma hepatocellular carcinoma	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding transcription factor binding phosphatase binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding activating transcription factor binding type I transforming growth factor beta receptor binding enhancer binding protein homodimerization activity SMAD binding metal ion binding protein heterodimerization activity co-SMAD binding I-SMAD binding R-SMAD binding DNA binding	sma-3 (C. elegans) sma-2 (C. elegans)