RAPGEF2 - SMAD2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
RAPGEF2	ENSG00000109756	No diseases in record	No drugs in record	signal transducer activity Ras guanyl-nucleotide exchange factor activity GTPase activator activity calcium ion binding protein binding Rap guanyl-nucleotide exchange factor activity diacylglycerol binding PDZ domain binding cAMP binding beta-1 adrenergic receptor binding WW domain binding phosphatidic acid binding cGMP binding	pxf-1 (C. elegans)
SMAD2	ENSG00000175387	colorectal carcinoma hepatocellular carcinoma	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding transcription factor binding phosphatase binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding activating transcription factor binding type I transforming growth factor beta receptor binding enhancer binding protein homodimerization activity SMAD binding metal ion binding protein heterodimerization activity co-SMAD binding I-SMAD binding R-SMAD binding DNA binding	sma-3 (C. elegans) sma-2 (C. elegans)