SMAD7 - MSH6

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SMAD7	ENSG00000101665	No diseases in record	No drugs in record	transcription factor activity, sequence-specific DNA binding protein binding collagen binding beta-catenin binding transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ubiquitin protein ligase binding type I transforming growth factor beta receptor binding transcription regulatory region DNA binding metal ion binding activin binding I-SMAD binding	daf-14 (C. elegans) daf-8 (C. elegans) Dad (D. melanogaster)
MSH6	ENSG00000116062	colorectal endometrial ovarian	No drugs in record	chromatin binding protein binding mismatched DNA binding methylated histone binding protein homodimerization activity magnesium ion binding four-way junction DNA binding double-stranded DNA binding ATP binding ATPase activity guanine/thymine mispair binding single guanine insertion binding single thymine insertion binding oxidized purine DNA binding MutLalpha complex binding ADP binding DNA binding nucleotide binding single base insertion or deletion binding damaged DNA binding	MSH6 (S. cerevisiae) msh-6 (C. elegans) Msh6 (D. melanogaster)