CCND1 - SMAD4

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
CCND1	ENSG00000110092	CLL B-ALL breast	PALBOCICLIB	transcription corepressor activity protein kinase activity protein binding transcription factor binding cyclin-dependent protein serine/threonine kinase regulator activity enzyme binding protein kinase binding protein complex binding histone deacetylase binding proline-rich region binding	cyd-1 (C. elegans) CycD (D. melanogaster)
SMAD4	ENSG00000141646	colorectal pancreatic small intestine gastrointestinal polyp	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding chromatin binding protein binding collagen binding transforming growth factor beta receptor, common-partner cytoplasmic mediator activity identical protein binding protein homodimerization activity transcription regulatory region DNA binding metal ion binding protein heterodimerization activity I-SMAD binding R-SMAD binding transcription factor activity, protein binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding	Med (D. melanogaster)