ESR1 - ERBB2

H. sapiens

SDL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
ESR1	ENSG00000091831	breast	BAZEDOXIFENE DIENESTROL DIETHYLSTILBESTROL DIETHYLSTILBESTROL DIPHOSPHATE ENCLOMIPHENE ESTRADIOL ESTRADIOL ACETATE ESTRADIOL CYPIONATE ESTRADIOL VALERATE ESTROGENS, CONJUGATED ESTROGENS, CONJUGATED SYNTHETIC A ESTROGENS, ESTERIFIED ESTRONE ESTRONE SULFURIC ACID ETHINYL ESTRADIOL FULVESTRANT MESTRANOL OSPEMIFENE POLYESTRADIOL PHOSPHATE QUINESTROL RALOXIFENE SYNTHETIC CONJUGATED ESTROGENS, B TAMOXIFEN TOREMIFENE	RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity steroid binding protein binding beta-catenin binding transcription factor binding zinc ion binding enzyme binding nitric-oxide synthase regulator activity estrogen receptor activity estrogen response element binding RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding identical protein binding ATPase binding	No GO terms in record
ERBB2	ENSG00000141736	breast ovarian other tumour types NSCLC gastric	AFATINIB LAPATINIB PERTUZUMAB TRASTUZUMAB TRASTUZUMAB EMTANSINE VANDETANIB	RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity growth factor binding	let-23 (C. elegans) Egfr (D. melanogaster)