JAK2 - ALK

H. sapiens

SDL interaction

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
JAK2 ENSG00000096968 ALL
AML
MPN
CML
RUXOLITINIB
TOFACITINIB
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
growth hormone receptor binding
interleukin-12 receptor binding
protein binding
ATP binding
protein C-terminus binding
protein kinase binding
heme binding
type 1 angiotensin receptor binding
acetylcholine receptor binding
histone kinase activity (H3-Y41 specific)
SH2 domain binding
histone binding
phosphatidylinositol 3-kinase binding
insulin receptor substrate binding
metal ion binding
peptide hormone receptor binding
hop (D. melanogaster)
ALK ENSG00000171094 ALCL
NSCLC
neuroblastoma
inflammatory myofibroblastic tumour
Spitzoid tumour
CERITINIB
CRIZOTINIB
NF-kappaB-inducing kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
identical protein binding
scd-2 (C. elegans)