UBR5 - SMAD4

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
UBR5	ENSG00000104517	mantle cell lymphoma gastric colorectal	No drugs in record	RNA binding ubiquitin-protein transferase activity protein binding zinc ion binding ubiquitin-ubiquitin ligase activity ubiquitin binding	TOM1 (S. cerevisiae) ubr-5 (C. elegans) hyd (D. melanogaster)
SMAD4	ENSG00000141646	colorectal pancreatic small intestine gastrointestinal polyp	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding chromatin binding protein binding collagen binding transforming growth factor beta receptor, common-partner cytoplasmic mediator activity identical protein binding protein homodimerization activity transcription regulatory region DNA binding metal ion binding protein heterodimerization activity I-SMAD binding R-SMAD binding transcription factor activity, protein binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding	Med (D. melanogaster)