EGFR - INSR

H. sapiens

SDL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
EGFR	ENSG00000146648	glioma NSCLC	AFATINIB CETUXIMAB ERLOTINIB GEFITINIB LAPATINIB PANITUMUMAB VANDETANIB	glycoprotein binding chromatin binding double-stranded DNA binding MAP kinase kinase kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity transmembrane signaling receptor activity epidermal growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity integrin binding protein binding calmodulin binding ATP binding enzyme binding protein kinase binding protein phosphatase binding ubiquitin protein ligase binding identical protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity epidermal growth factor binding actin filament binding cadherin binding involved in cell-cell adhesion nitric-oxide synthase regulator activity protein domain specific binding	let-23 (C. elegans) Egfr (D. melanogaster)
INSR	ENSG00000171105	No diseases in record	INSULIN ASPART INSULIN ASPART PROTAMINE RECOMBINANT INSULIN DETEMIR INSULIN GLARGINE INSULIN GLULISINE INSULIN HUMAN INSULIN LISPRO INSULIN LISPRO PROTAMINE RECOMBINANT INSULIN PORK INSULIN PURIFIED BEEF INSULIN PURIFIED PORK INSULIN SUSP ISOPHANE BEEF INSULIN SUSP ISOPHANE BEEF/PORK INSULIN SUSP ISOPHANE PURIFIED BEEF INSULIN SUSP ISOPHANE PURIFIED PORK INSULIN SUSP ISOPHANE RECOMBINANT HUMAN INSULIN SUSP ISOPHANE SEMISYNTHETIC PURIFIED HUMAN INSULIN SUSP PROTAMINE ZINC BEEF/PORK INSULIN SUSP PROTAMINE ZINC PURIFIED BEEF INSULIN SUSP PROTAMINE ZINC PURIFIED PORK INSULIN ZINC SUSP BEEF INSULIN ZINC SUSP EXTENDED BEEF INSULIN ZINC SUSP EXTENDED PURIFIED BEEF INSULIN ZINC SUSP EXTENDED RECOMBINANT HUMAN INSULIN ZINC SUSP PROMPT BEEF INSULIN ZINC SUSP PROMPT PURIFIED PORK INSULIN ZINC SUSP PURIFIED BEEF INSULIN ZINC SUSP PURIFIED BEEF/PORK INSULIN ZINC SUSP PURIFIED PORK INSULIN ZINC SUSP RECOMBINANT HUMAN INSULIN ZINC SUSP SEMISYNTHETIC PURIFIED HUMAN	protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding protein binding ATP binding GTP binding insulin-like growth factor I binding insulin-like growth factor II binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding PTB domain binding	daf-2 (C. elegans)