PPP3CA - SMAD2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PPP3CA	ENSG00000138814	No diseases in record	No drugs in record	protein serine/threonine phosphatase activity calcium ion binding protein binding calmodulin binding drug binding enzyme binding calmodulin-dependent protein phosphatase activity protein heterodimerization activity protein dimerization activity	CMP2 (S. cerevisiae) CNA1 (S. cerevisiae) tax-6 (C. elegans) CanA1 (D. melanogaster) Pp2B-14D (D. melanogaster)
SMAD2	ENSG00000175387	colorectal carcinoma hepatocellular carcinoma	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding transcription factor binding phosphatase binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding activating transcription factor binding type I transforming growth factor beta receptor binding enhancer binding protein homodimerization activity SMAD binding metal ion binding protein heterodimerization activity co-SMAD binding I-SMAD binding R-SMAD binding DNA binding	sma-3 (C. elegans) sma-2 (C. elegans)