SMAD2 - PPME1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SMAD2	ENSG00000175387	colorectal carcinoma hepatocellular carcinoma	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding transcription factor binding phosphatase binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding activating transcription factor binding type I transforming growth factor beta receptor binding enhancer binding protein homodimerization activity SMAD binding metal ion binding protein heterodimerization activity co-SMAD binding I-SMAD binding R-SMAD binding DNA binding	sma-3 (C. elegans) sma-2 (C. elegans)
PPME1	ENSG00000214517	No diseases in record	No drugs in record	protein phosphatase inhibitor activity protein phosphatase regulator activity protein kinase binding protein phosphatase binding protein phosphatase 2A binding protein C-terminal methylesterase activity cadherin binding involved in cell-cell adhesion	PPE1 (S. cerevisiae) B0464.9 (C. elegans) CG5068 (D. melanogaster)