PICALM - RAF1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PICALM	ENSG00000073921	T-ALL AML	No drugs in record	protein binding 1-phosphatidylinositol binding clathrin binding clathrin heavy chain binding clathrin adaptor activity cadherin binding involved in cell-cell adhesion	YAP1801 (S. cerevisiae) YAP1802 (S. cerevisiae) unc-11 (C. elegans) lap (D. melanogaster)
RAF1	ENSG00000132155	pilocytic astrocytoma prostate	REGORAFENIB SORAFENIB	protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding kinase activity enzyme binding mitogen-activated protein kinase kinase binding identical protein binding metal ion binding protein heterodimerization activity small GTPase binding	lin-45 (C. elegans)