TDP1 - HDAC1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TDP1	ENSG00000042088	No diseases in record	No drugs in record	double-stranded DNA binding single-stranded DNA binding exonuclease activity protein binding 3'-tyrosyl-DNA phosphodiesterase activity hydrolase activity nuclease activity 5'-tyrosyl-DNA phosphodiesterase activity phosphoric diester hydrolase activity	TDP1 (S. cerevisiae) gkt (D. melanogaster)
HDAC1	ENSG00000116478	No diseases in record	BELINOSTAT PANOBINOSTAT ROMIDEPSIN VORINOSTAT	transcription regulatory region sequence-specific DNA binding core promoter binding RNA polymerase II transcription factor binding RNA polymerase II repressing transcription factor binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding histone deacetylase activity protein binding transcription factor binding deacetylase activity enzyme binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity activating transcription factor binding histone deacetylase binding transcription regulatory region DNA binding protein N-terminus binding NF-kappaB binding repressing transcription factor binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding nucleosomal DNA binding	RPD3 (S. cerevisiae) hda-1 (C. elegans) hda-3 (C. elegans)