HSP90AA1 - JAK2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
HSP90AA1	ENSG00000080824	NHL	No drugs in record	nucleotide binding glycoprotein binding UTP binding CTP binding mRNA binding protein tyrosine kinase activity protein binding ATP binding GTP binding ATPase activity sulfonylurea receptor binding protein phosphatase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding dATP binding identical protein binding protein homodimerization activity histone deacetylase binding ion channel binding tau protein binding GTPase binding Rho GDP-dissociation inhibitor binding unfolded protein binding protein tyrosine kinase binding	HSC82 (S. cerevisiae) HSP82 (S. cerevisiae) daf-21 (C. elegans) Hsp83 (D. melanogaster)
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)