TOP2A - MUS81

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP2A	ENSG00000131747	No diseases in record	DAUNORUBICIN DOXORUBICIN EPIRUBICIN ETOPOSIDE ETOPOSIDE PHOSPHATE IDARUBICIN MITOXANTRONE PODOFILOX TENIPOSIDE VALRUBICIN	magnesium ion binding DNA binding chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding protein C-terminus binding DNA-dependent ATPase activity drug binding DNA binding, bending enzyme binding protein homodimerization activity histone deacetylase binding ubiquitin binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)
MUS81	ENSG00000172732	No diseases in record	No drugs in record	DNA binding endodeoxyribonuclease activity protein binding metal ion binding 3'-flap endonuclease activity crossover junction endodeoxyribonuclease activity nuclease activity endonuclease activity enzyme inhibitor activity hydrolase activity	MUS81 (S. cerevisiae) mus81 (D. melanogaster)