TOP2A - PIF1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP2A	ENSG00000131747	No diseases in record	DAUNORUBICIN DOXORUBICIN EPIRUBICIN ETOPOSIDE ETOPOSIDE PHOSPHATE IDARUBICIN MITOXANTRONE PODOFILOX TENIPOSIDE VALRUBICIN	magnesium ion binding DNA binding chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding protein C-terminus binding DNA-dependent ATPase activity drug binding DNA binding, bending enzyme binding protein homodimerization activity histone deacetylase binding ubiquitin binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)
PIF1	ENSG00000140451	No diseases in record	No drugs in record	magnesium ion binding ATP binding telomerase inhibitor activity single-stranded DNA-dependent ATP-dependent DNA helicase activity ATP-dependent 5'-3' DNA/RNA helicase activity telomeric DNA binding ATP-dependent 5'-3' DNA helicase activity G-quadruplex DNA binding hydrolase activity nucleotide binding helicase activity single-stranded DNA binding DNA helicase activity DNA binding	PIF1 (S. cerevisiae) RRM3 (S. cerevisiae)