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SIRT1 - TP53
H. sapiens
SDL interaction
Identifiers
Gene Name
Gene ID
Diseases
Drugs
GO terms
Orthologs
SIRT1
ENSG00000096717
No diseases in record
No drugs in record
core promoter sequence-specific DNA binding
p53 binding
transcription corepressor activity
histone deacetylase activity
protein binding
protein C-terminus binding
transcription factor binding
NAD-dependent histone deacetylase activity
deacetylase activity
enzyme binding
protein deacetylase activity
NAD-dependent protein deacetylase activity
nuclear hormone receptor binding
histone binding
identical protein binding
HLH domain binding
bHLH transcription factor binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
mitogen-activated protein kinase binding
NAD+ binding
keratin filament binding
NAD+ ADP-ribosyltransferase activity
HST1 (S. cerevisiae)
SIR2 (S. cerevisiae)
sir-2.1 (C. elegans)
TP53
ENSG00000141510
breast
colorectal
lung
sarcoma
adrenocortical
glioma
Spitzoid tumour
multiple other tumour types
adrenocortical carcinoma
No drugs in record
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protease binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
copper ion binding
protein binding
ATP binding
transcription factor binding
zinc ion binding
enzyme binding
protein kinase binding
protein phosphatase binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
identical protein binding
sequence-specific DNA binding
protein self-association
transcription regulatory region DNA binding
protein heterodimerization activity
protein N-terminus binding
chaperone binding
protein phosphatase 2A binding
No GO terms in record