AGO1 - SIRT1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
AGO1	ENSG00000092847	No diseases in record	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding core promoter binding RNA binding double-stranded RNA binding single-stranded RNA binding protein binding miRNA binding endoribonuclease activity enzyme binding endoribonuclease activity, producing 5'-phosphomonoesters	alg-1 (C. elegans) alg-2 (C. elegans) AGO1 (D. melanogaster)
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)