SIRT1 - TIAM1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)
TIAM1	ENSG00000156299	No diseases in record	No drugs in record	signal transducer activity, downstream of receptor guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding microtubule binding lipid binding kinase binding Rac guanyl-nucleotide exchange factor activity receptor tyrosine kinase binding Rac GTPase binding	No GO terms in record