TCF7 - SIRT1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TCF7	ENSG00000081059	No diseases in record	No drugs in record	core promoter binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding beta-catenin binding sequence-specific DNA binding transcription regulatory region DNA binding	pop-1 (C. elegans) pan (D. melanogaster)
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)