SIRT1 - JUP

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)
JUP	ENSG00000173801	No diseases in record	No drugs in record	transcription coactivator activity signal transducer activity structural molecule activity structural constituent of cell wall protein binding protein kinase binding protein phosphatase binding protein homodimerization activity alpha-catenin binding cadherin binding cell adhesion molecule binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication cadherin binding involved in cell-cell adhesion	bar-1 (C. elegans) hmp-2 (C. elegans) arm (D. melanogaster)