TCF12 - WRN

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TCF12	ENSG00000140262	extraskeletal myxoid chondrosarcoma	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding enhancer binding cAMP response element binding protein homodimerization activity bHLH transcription factor binding SMAD binding protein heterodimerization activity E-box binding HMG box domain binding transcription regulatory region DNA binding	hlh-2 (C. elegans)
WRN	ENSG00000165392	osteosarcoma meningioma other tumour types	No drugs in record	magnesium ion binding Y-form DNA binding bubble DNA binding DNA binding DNA helicase activity chromatin binding ATP-dependent DNA helicase activity helicase activity exonuclease activity protein binding ATP binding 3'-5' exonuclease activity four-way junction helicase activity ATPase activity manganese ion binding protein complex binding protein homodimerization activity 3'-5' DNA helicase activity ATP-dependent 3'-5' DNA helicase activity G-quadruplex DNA binding	SGS1 (S. cerevisiae) wrn-1 (C. elegans)