JAK2 - RAPGEF2

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)
RAPGEF2	ENSG00000109756	No diseases in record	No drugs in record	signal transducer activity Ras guanyl-nucleotide exchange factor activity GTPase activator activity calcium ion binding protein binding Rap guanyl-nucleotide exchange factor activity diacylglycerol binding PDZ domain binding cAMP binding beta-1 adrenergic receptor binding WW domain binding phosphatidic acid binding cGMP binding	pxf-1 (C. elegans)