JAK2 - PKN1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)
PKN1	ENSG00000123143	No diseases in record	No drugs in record	chromatin binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein kinase C binding protein binding ATP binding GTP-Rho binding ligand-dependent nuclear receptor transcription coactivator activity histone kinase activity (H3-T11 specific) histone binding histone deacetylase binding Rac GTPase binding androgen receptor binding	PKC1 (S. cerevisiae) pkn-1 (C. elegans) Pkn (D. melanogaster)