CDC5L - JAK2

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
CDC5L	ENSG00000096401	No diseases in record	No drugs in record	RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor recruiting transcription corepressor binding DNA binding protein binding protein phosphatase 1 binding protein kinase binding leucine zipper domain binding sequence-specific DNA binding transcription regulatory region DNA binding WD40-repeat domain binding	CEF1 (S. cerevisiae) Cdc5 (D. melanogaster)
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)