JAK2 - PIM1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)
PIM1	ENSG00000137193	NHL	No drugs in record	protein serine/threonine kinase activity protein binding ATP binding transcription factor binding manganese ion binding ribosomal small subunit binding mitochondrial light strand promoter anti-sense binding serine-type peptidase activity ATP-dependent peptidase activity nucleotide binding peptidase activity single-stranded DNA binding serine-type endopeptidase activity hydrolase activity DNA binding Ran guanyl-nucleotide exchange factor activity	PSK1 (S. cerevisiae) PSK2 (S. cerevisiae)