JAK2 - CDC73

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)
CDC73	ENSG00000134371	parathyroid adenoma multiple ossifying jaw fibroma	No drugs in record	RNA polymerase II core binding protein binding chromatin binding transcription factor activity, TFIIF-class transcription factor binding RNA polymerase II C-terminal domain phosphoserine binding transcription factor activity, RNA polymerase II transcription factor binding molecular_function	CDC73 (S. cerevisiae) hyx (D. melanogaster) CG6220 (D. melanogaster)