JAK2 - SLC11A2

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)
SLC11A2	ENSG00000110911	No diseases in record	No drugs in record	copper ion transmembrane transporter activity iron ion transmembrane transporter activity manganese ion transmembrane transporter activity protein binding hydrogen ion transmembrane transporter activity cadmium ion transmembrane transporter activity cobalt ion transmembrane transporter activity ferrous iron transmembrane transporter activity lead ion transmembrane transporter activity solute:proton symporter activity ferrous iron uptake transmembrane transporter activity cadmium ion binding transition metal ion transmembrane transporter activity	SMF1 (S. cerevisiae) SMF2 (S. cerevisiae) SMF3 (S. cerevisiae) Mvl (D. melanogaster)