EXO1 - SMAD2

H. sapiens

SSL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
EXO1	ENSG00000174371	No diseases in record	No drugs in record	DNA binding chromatin binding RNA-DNA hybrid ribonuclease activity exonuclease activity protein binding 5'-3' exonuclease activity 5'-3' exodeoxyribonuclease activity single-stranded DNA 5'-3' exodeoxyribonuclease activity metal ion binding flap endonuclease activity double-stranded DNA 5'-3' exodeoxyribonuclease activity 5'-flap endonuclease activity hydrolase activity catalytic activity nuclease activity hydrolase activity, acting on ester bonds double-stranded DNA binding	DIN7 (S. cerevisiae) EXO1 (S. cerevisiae) exo-1 (C. elegans) tos (D. melanogaster)
SMAD2	ENSG00000175387	colorectal carcinoma hepatocellular carcinoma	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding transcription factor binding phosphatase binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding activating transcription factor binding type I transforming growth factor beta receptor binding enhancer binding protein homodimerization activity SMAD binding metal ion binding protein heterodimerization activity co-SMAD binding I-SMAD binding R-SMAD binding DNA binding	sma-3 (C. elegans) sma-2 (C. elegans)