SIRT1 - PGAM5

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)
PGAM5	ENSG00000247077	No diseases in record	No drugs in record	GTPase activator activity signal transducer, downstream of receptor, with serine/threonine phosphatase activity phosphatase activity protein complex binding protein serine/threonine kinase activator activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity phosphoglycerate mutase activity kinase binding protein binding	Pgam5 (D. melanogaster) Pgam5-2 (D. melanogaster)